There aren't any case consider harddisk speed.
If I have 5 TB harddisk with 150 MB read speed, how many connect can be handled ?
Every case and every load is individual and there's no easy way to handle it just by calculations.
It also heavily depends streaming scenario, RAMcache size is used and if connection's chunk request hits the cache.
I suggest benchmarking on your hardware with your streaming scenario.
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